5 EASY FACTS ABOUT PKRRATING DESCRIBED

The activated enzyme then phosphorylates its major substrate, the translational initiation aspect eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to your conserved household of four protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to distinct stimuli12, triggering the built-in anxiety